{"id":48612,"date":"2026-10-19T16:13:06","date_gmt":"2026-10-19T13:13:06","guid":{"rendered":"https:\/\/kuzeyinsesi.org\/index.php\/2026\/10\/19\/probiyotikler-hafizayi-korumaya-yardimci-olabilir\/"},"modified":"2026-10-19T16:13:06","modified_gmt":"2026-10-19T13:13:06","slug":"probiyotikler-hafizayi-korumaya-yardimci-olabilir","status":"publish","type":"post","link":"https:\/\/kuzeyinsesi.org\/index.php\/2026\/10\/19\/probiyotikler-hafizayi-korumaya-yardimci-olabilir\/","title":{"rendered":"Probiyotikler haf\u0131zay\u0131 korumaya yard\u0131mc\u0131 olabilir"},"content":{"rendered":"

<\/p>\n

\n


\n\tYeni bir klinik ara\u015ft\u0131rma, belirli probiyotik kar\u0131\u015f\u0131mlar\u0131n\u0131n bili\u015fsel gerilemenin baz\u0131 erken belirtilerine kar\u015f\u0131 koruma sa\u011flayabilece\u011fine ili\u015fkin bulgular ortaya koydu.<\/p>\n


\n\tErken bili\u015fsel bozuklu\u011fu bulunan ya\u015fl\u0131 yeti\u015fkinler \u00fczerinde y\u00fcr\u00fct\u00fclen ara\u015ft\u0131rmada, yakla\u015f\u0131k alt\u0131 ay boyunca her g\u00fcn birden fazla bakteri t\u00fcr\u00fc i\u00e7eren probiyotik takviyesi kullanman\u0131n \u00e7e\u015fitli yararlar\u0131 g\u00f6r\u00fcld\u00fc.<\/p>\n


\n\t\u00d6zellikle plasebo verilen grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, probiyotik kullanan kat\u0131l\u0131mc\u0131lar\u0131n \u00e7e\u015fitli bili\u015fsel testlerde daha iyi sonu\u00e7lar ald\u0131\u011f\u0131 belirlendi.<\/p>\n


\n\tAyr\u0131ca kan plazmas\u0131ndaki pTau181 d\u00fczeylerinde anlaml\u0131 d\u00fc\u015f\u00fc\u015f g\u00f6r\u00fcld\u00fc.<\/p>\n


\n\tpTau181, Alzheimer<\/a> hastal\u0131\u011f\u0131yla ili\u015fkili de\u011fi\u015fiklikleri yans\u0131tabilen, kanda \u00f6l\u00e7\u00fclen bir biyobelirte\u00e7.<\/p>\n


\n\tBu belirte\u00e7, tau proteininin fosforillenmi\u015f bir formunu \u00f6l\u00e7\u00fcyor.<\/p>\n


\n\tDemans<\/a> vakalar\u0131nda tau proteinleri anormal \u015fekilde katlanarak beyin h\u00fccrelerinin i\u015fleyi\u015fini bozabilen yumaklar olu\u015fturabiliyor.<\/p>\n


\n\tDemans belirtileri ortaya \u00e7\u0131kmadan \u00f6nce pTau181 d\u00fczeyleri de s\u0131kl\u0131kla y\u00fckseliyor.<\/p>\n


\n\tJournal of Alzheimer’s Disease dergisinde yay\u0131mlanan bulgular umut verici olsa da hen\u00fcz kesin sonu\u00e7lar sunmuyor.<\/p>\n


\n\tAra\u015ft\u0131rma, probiyotiklerin beyindeki tau protein yumaklar\u0131n\u0131 do\u011frudan azaltt\u0131\u011f\u0131n\u0131 g\u00f6stermiyor.<\/p>\n


\n\tBununla birlikte sonu\u00e7lar, ba\u011f\u0131rsak<\/a> mikrobiyotas\u0131 ile beyin sa\u011fl\u0131\u011f\u0131 aras\u0131nda yak\u0131n bir ili\u015fki bulundu\u011funa i\u015faret eden giderek b\u00fcy\u00fcyen bilimsel kan\u0131tlara katk\u0131 sa\u011fl\u0131yor.<\/p>\n


\n\tBa\u011f\u0131rsak mikrobiyotas\u0131, gelecekte demans tedavileri a\u00e7\u0131s\u0131ndan da \u00f6nemli bir hedef olabilir.<\/p>\n


\n\t87 kat\u0131l\u0131mc\u0131yla y\u00fcr\u00fct\u00fcld\u00fc<\/h2>\n


\n\tG\u00fcney Kore’de y\u00fcr\u00fct\u00fclen ara\u015ft\u0131rmaya, bili\u015fsel gerilemeyi uzun vadeli olarak inceleyen Gwangju Alzheimer Hastal\u0131\u011f\u0131 ve \u0130li\u015fkili Demanslar (GARD) kohort \u00e7al\u0131\u015fmas\u0131ndan 87 ki\u015fi kat\u0131ld\u0131.<\/p>\n


\n\tBa\u015flang\u0131\u00e7ta 100 ki\u015fi rastgele gruplara ayr\u0131ld\u0131.<\/p>\n


\n\tBunlardan 40’\u0131 24 haftal\u0131k probiyotik uygulamas\u0131n\u0131, 47’si ise plasebo uygulamas\u0131n\u0131 tamamlad\u0131.<\/p>\n


\n\tNe kat\u0131l\u0131mc\u0131lar ne de ara\u015ft\u0131rmac\u0131lar kimin hangi \u00fcr\u00fcn\u00fc kulland\u0131\u011f\u0131n\u0131 bilmiyordu.<\/p>\n


\n\tAra\u015ft\u0131rmada kullan\u0131lan KL-P301 kodlu probiyotik takviyesi \u00fc\u00e7 bakteri t\u00fcr\u00fcn\u00fc i\u00e7eriyordu: Bifidobacterium animalis, Limosilactobacillus fermentum ve Levilactobacillus brevis alt t\u00fcrleri.<\/p>\n


\n\tKat\u0131l\u0131mc\u0131lar toz \u00fcr\u00fcn\u00fc do\u011frudan t\u00fcketebiliyor veya suya kar\u0131\u015ft\u0131rabiliyordu.<\/p>\n


\n\t24 haftan\u0131n sonunda probiyotik kullanan grupta kandaki pTau181 d\u00fczeyleri, plasebo grubuna k\u0131yasla anlaml\u0131 \u00f6l\u00e7\u00fcde azald\u0131.<\/p>\n


\n\tKat\u0131l\u0131mc\u0131lar\u0131n Klinik Demans Derecelendirme \u00f6l\u00e7e\u011findeki puanlar\u0131nda da anlaml\u0131 iyile\u015fme g\u00f6r\u00fcld\u00fc.<\/p>\n


\n\tG\u00f6rsel bilgileri yorumlama, mek\u00e2nsal ili\u015fkileri anlama ve karma\u015f\u0131k \u015fekiller \u00e7izme gibi becerileri \u00f6l\u00e7en baz\u0131 testlerde de geli\u015fme kaydedildi.<\/p>\n


\n\tAncak bu sonu\u00e7lar\u0131n tamam\u0131nda plasebo grubuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda istatistiksel anlaml\u0131l\u0131k sa\u011flanmad\u0131.<\/p>\n


\n\tAra\u015ft\u0131rmac\u0131lar, kandaki pTau181 d\u00fczeylerinin d\u00fc\u015fmesiyle g\u00f6rsel-mek\u00e2nsal beceriler ve g\u00f6rsel belle\u011fin korunmas\u0131na ili\u015fkin bulgular\u0131n, ba\u011f\u0131rsak, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi ve beyin aras\u0131ndaki etkile\u015fimin erken n\u00f6rodejeneratif s\u00fcre\u00e7lerde rol oynayabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrd\u00fc\u011f\u00fcn\u00fc belirtti.<\/p>\n


\n\tBa\u011f\u0131rsak ve beyin aras\u0131ndaki ba\u011flant\u0131<\/h2>\n


\n\tProbiyotiklerle ilgili daha \u00f6nce yap\u0131lan baz\u0131 klinik ara\u015ft\u0131rmalarda da benzer sonu\u00e7lar elde edilmi\u015fti. Alzheimer tan\u0131s\u0131 konulan hastalarda Bifidobacterium ve Lactobacillus t\u00fcrlerini i\u00e7eren \u00e7oklu probiyotik takviyelerinin, kan dola\u015f\u0131m\u0131ndaki baz\u0131 beyin kaynakl\u0131 belirte\u00e7lerle olumlu y\u00f6nde ili\u015fkili oldu\u011fu g\u00f6r\u00fclm\u00fc\u015ft\u00fc.<\/p>\n


\n\tBu takviyeler ayr\u0131ca iltihaplanma ve oksidatif stresle ili\u015fkili baz\u0131 belirte\u00e7lerin d\u00fc\u015fmesiyle ili\u015fkilendirilmi\u015fti.<\/p>\n


\n\tYeni ara\u015ft\u0131rmada ise tau proteiniyle ili\u015fkili kan belirte\u00e7leri bili\u015fsel i\u015flevlerle birlikte incelendi.<\/p>\n


\n\t24 hafta sonunda iltihaplanma belirte\u00e7lerinin \u00e7o\u011fundaki de\u011fi\u015fim s\u0131n\u0131rl\u0131 kald\u0131. Ancak IL-1\u03b2 ad\u0131 verilen bir belirte\u00e7, probiyotik grubunda plasebo grubuna k\u0131yasla daha fazla azald\u0131.<\/p>\n


\n\tAra\u015ft\u0131rmac\u0131lara g\u00f6re bu bulgu, \u00e7oklu probiyotik kar\u0131\u015f\u0131m\u0131n\u0131n belirli sitokin yollar\u0131 \u00fczerinde se\u00e7ici bir iltihap azalt\u0131c\u0131 etki g\u00f6sterebilece\u011fine i\u015faret ediyor.<\/p>\n


\n\tBa\u015fka bir ifadeyle probiyotikler ba\u011f\u0131rsak sa\u011fl\u0131\u011f\u0131n\u0131 iyile\u015ftirebilir ve beyni etkileyebilecek baz\u0131 sistemik iltihaplanma sinyallerini azaltabilir. Bu s\u00fcre\u00e7, kandaki tau belirte\u00e7lerinin azalmas\u0131na katk\u0131da bulunabilir.<\/p>\n


\n\tBa\u011f\u0131rsak sa\u011fl\u0131\u011f\u0131n\u0131n bozulmas\u0131, kan-beyin bariyerini zay\u0131flatabilecek, beyinde iltihaplanmaya yol a\u00e7abilecek veya sinir h\u00fccrelerine zarar verebilecek ba\u011f\u0131\u015f\u0131kl\u0131k tepkilerini tetikleyebilir. Ancak probiyotiklerin ba\u011f\u0131rsak sa\u011fl\u0131\u011f\u0131n\u0131 ne \u00f6l\u00e7\u00fcde iyile\u015ftirebildi\u011fi ve bu etkilerin beyne nas\u0131l yans\u0131d\u0131\u011f\u0131 hen\u00fcz tam olarak anla\u015f\u0131lm\u0131\u015f de\u011fil.<\/p>\n


\n\tHayvan deneylerinde olumlu sonu\u00e7lar elde edilse de bu sonu\u00e7lar her zaman insanlarda tekrarlanm\u0131yor. Bu nedenle daha b\u00fcy\u00fck kat\u0131l\u0131mc\u0131 gruplar\u0131yla y\u00fcr\u00fct\u00fclecek klinik ara\u015ft\u0131rmalara ihtiya\u00e7 duyuluyor.<\/p>\n


\n\tAra\u015ft\u0131rmac\u0131lar, elde edilen bulgular\u0131n do\u011frulanmas\u0131, etkilerin ne kadar s\u00fcrd\u00fc\u011f\u00fcn\u00fcn ve klinik a\u00e7\u0131dan ne kadar anlaml\u0131 oldu\u011funun belirlenmesi i\u00e7in daha uzun s\u00fcreli ve kapsaml\u0131 \u00e7al\u0131\u015fmalara ihtiya\u00e7 oldu\u011funu vurgulad\u0131.<\/p>\n


\n\tAra\u015ft\u0131rma<\/a> ekibi, \u00e7oklu probiyotik form\u00fclasyonunun Alzheimer hastal\u0131\u011f\u0131n\u0131n erken evrelerinde ila\u00e7 d\u0131\u015f\u0131 bir yakla\u015f\u0131m olarak kullan\u0131lma potansiyelinin daha ayr\u0131nt\u0131l\u0131 incelenmesi gerekti\u011fi sonucuna vard\u0131.<\/p>\n


\n\tAra\u015ft\u0131rma, Journal of Alzheimer’s Disease dergisinde yay\u0131mland\u0131.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Yeni bir klinik ara\u015ft\u0131rma, belirli probiyotik kar\u0131\u015f\u0131mlar\u0131n\u0131n bili\u015fsel gerilemenin baz\u0131 erken belirtilerine kar\u015f\u0131 koruma sa\u011flayabilece\u011fine ili\u015fkin bulgular ortaya koydu. Erken bili\u015fsel bozuklu\u011fu bulunan ya\u015fl\u0131 yeti\u015fkinler \u00fczerinde y\u00fcr\u00fct\u00fclen ara\u015ft\u0131rmada, yakla\u015f\u0131k alt\u0131 ay boyunca her g\u00fcn birden fazla bakteri t\u00fcr\u00fc i\u00e7eren probiyotik takviyesi kullanman\u0131n \u00e7e\u015fitli yararlar\u0131 g\u00f6r\u00fcld\u00fc. \u00d6zellikle plasebo verilen grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, probiyotik kullanan […]<\/p>\n","protected":false},"author":1,"featured_media":33504,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-48612","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\nProbiyotikler haf\u0131zay\u0131 korumaya yard\u0131mc\u0131 olabilir - Kuzeyin Sesi<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/kuzeyinsesi.org\/index.php\/2026\/10\/19\/probiyotikler-hafizayi-korumaya-yardimci-olabilir\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Probiyotikler haf\u0131zay\u0131 korumaya yard\u0131mc\u0131 olabilir - Kuzeyin Sesi\" \/>\n<meta property=\"og:description\" content=\" Yeni bir klinik ara\u015ft\u0131rma, belirli probiyotik kar\u0131\u015f\u0131mlar\u0131n\u0131n bili\u015fsel gerilemenin baz\u0131 erken belirtilerine kar\u015f\u0131 koruma sa\u011flayabilece\u011fine ili\u015fkin bulgular ortaya koydu. 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