{"id":47892,"date":"2026-10-06T09:24:04","date_gmt":"2026-10-06T06:24:04","guid":{"rendered":"https:\/\/kuzeyinsesi.org\/index.php\/2026\/10\/06\/yeni-antikor-tedavisi-normal-agriyi-engellemeden-sinir-agrisini-gunlerce-dindiriyor\/"},"modified":"2026-10-06T09:24:04","modified_gmt":"2026-10-06T06:24:04","slug":"yeni-antikor-tedavisi-normal-agriyi-engellemeden-sinir-agrisini-gunlerce-dindiriyor","status":"publish","type":"post","link":"https:\/\/kuzeyinsesi.org\/index.php\/2026\/10\/06\/yeni-antikor-tedavisi-normal-agriyi-engellemeden-sinir-agrisini-gunlerce-dindiriyor\/","title":{"rendered":"Yeni antikor tedavisi normal a\u011fr\u0131y\u0131 engellemeden sinir a\u011fr\u0131s\u0131n\u0131 g\u00fcnlerce dindiriyor"},"content":{"rendered":"<p><\/p>\n<div>\n<p>&#13;<br \/>\n\tN\u00f6ropatik a\u011fr\u0131, hasarl\u0131 sinirlerin yeni bir doku hasar\u0131 olmasa bile <a href=\"https:\/\/www.trthaber.com\/etiket\/agri\/\" target=\"_blank\">a\u011fr\u0131<\/a> sinyalleri g\u00f6ndermeye devam etmesi nedeniyle bir yaralanmadan sonra devam edebiliyor.<\/p>\n<p>&#13;<br \/>\n\tYap\u0131lan yeni bir klinik \u00f6ncesi \u00e7al\u0131\u015fmada ara\u015ft\u0131rmac\u0131lar, a\u011fr\u0131yla ili\u015fkili bir sodyum kanal\u0131n\u0131 hedef alan antikorlar\u0131n, farelerde normal koruyucu a\u011fr\u0131 hissini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde sa\u011flam b\u0131rak\u0131rken anormal sinir sinyallerini g\u00fcnlerce bast\u0131rabildi\u011fini tespit etti.<\/p>\n<p>&#13;<br \/>\n\tDeneysel antikorlar, a\u011fr\u0131yla ilgili <a href=\"https:\/\/www.trthaber.com\/etiket\/elektrik\/\" target=\"_blank\">elektrik<\/a> sinyallerinin \u00fcretilmesine ve iletilmesine yard\u0131mc\u0131 olan duyusal n\u00f6ronlarda bulunan voltaj kap\u0131l\u0131 bir sodyum kanal\u0131 olan Nav1.7&#8217;yi hedef al\u0131yor.<\/p>\n<h2>&#13;<br \/>\n\t\u00d6nemli bir a\u011fr\u0131 kanal\u0131n\u0131n hedeflenmesi<\/h2>\n<p>&#13;<br \/>\n\tToyama \u00dcniversitesinden Do\u00e7ent Daisuke Uta ve Shionogi firmas\u0131ndan Doktor Sosuke Yoneda, Nav1.7&#8217;yi tan\u0131yacak \u015fekilde tasarlanm\u0131\u015f antikorlar\u0131n n\u00f6ropatik a\u011fr\u0131dan kal\u0131c\u0131 bir rahatlama sa\u011flay\u0131p sa\u011flayamayaca\u011f\u0131n\u0131 ara\u015ft\u0131rd\u0131. <a href=\"https:\/\/www.trthaber.com\/etiket\/arastirma\/\" target=\"_blank\">Ara\u015ft\u0131rma<\/a> sonu\u00e7lar\u0131 Pharmaceutics dergisinde yay\u0131mland\u0131.<\/p>\n<p>&#13;<br \/>\n\tDoktor Uta, Nav1.7&#8217;nin sinir h\u00fccrelerinde a\u011fr\u0131 sinyallerini alg\u0131lamada ve iletmede \u00f6nemli bir rol oynayan \u00f6zel bir sodyum iyon kanal\u0131 oldu\u011funu s\u00f6yledi.<\/p>\n<p>&#13;<br \/>\n\tEkip insanla\u015ft\u0131r\u0131lm\u0131\u015f antikorlar geli\u015ftirdi ve bunlar\u0131 ilk olarak h\u00fccrelerde test etti. Clone1 ve S-151128 adl\u0131 iki aday, Nav1.7&#8217;ye g\u00fc\u00e7l\u00fc bir \u015fekilde ba\u011flanarak a\u011fr\u0131 sinyaliyle ili\u015fkili elektriksel aktiviteyi azaltt\u0131. Clone1, test edilen di\u011fer Nav alt tiplerine g\u00f6re Nav1.7 i\u00e7in en az 650 kat se\u00e7icilik g\u00f6sterirken, S-151128 en az 1300 kat se\u00e7icilik g\u00f6sterdi.<\/p>\n<h2>&#13;<br \/>\n\tG\u00fcnlerce s\u00fcren a\u011fr\u0131 kesici etki<\/h2>\n<p>&#13;<br \/>\n\tAra\u015ft\u0131rmac\u0131lar daha sonra antikorlar\u0131, sinir hasar\u0131n\u0131n neden oldu\u011fu n\u00f6ropatik a\u011fr\u0131 modeli olan k\u0131smi siyatik sinir ligasyonuna sahip farelerde test etti. Antikorlar deneklere damar yoluyla uyguland\u0131.<\/p>\n<p>&#13;<br \/>\n\tHer iki antikor da hayvanlar\u0131n mekanik uyar\u0131lara kar\u015f\u0131 duyarl\u0131l\u0131\u011f\u0131n\u0131 doza ba\u011fl\u0131 bir \u015fekilde azaltt\u0131. Baz\u0131 dozlarda etkiler, n\u00f6ropatik a\u011fr\u0131 i\u00e7in yayg\u0131n olarak kullan\u0131lan bir ila\u00e7 olan pregabalin ile kar\u015f\u0131la\u015ft\u0131r\u0131labilir d\u00fczeydeydi. Ancak 96 saat sonra antikorlardan sa\u011flanan a\u011fr\u0131 kesici etki, pregabalinin yaratt\u0131\u011f\u0131 etkiden daha g\u00fc\u00e7l\u00fc kalmaya devam etti.<\/p>\n<p>&#13;<br \/>\n\t<a href=\"https:\/\/www.trthaber.com\/etiket\/sinir-sistemi\/\" target=\"_blank\">Sinir sistemi<\/a> \u00f6l\u00e7\u00fcmleri de benzer bir tablo ortaya koydu. Sinir hasar\u0131ndan sonra, omurilik arka boynuzundaki n\u00f6ronlar artan spontan aktivite ve mekanik uyar\u0131lara kar\u015f\u0131 daha g\u00fc\u00e7l\u00fc tepkiler g\u00f6sterdi. Antikor tedavisi her ikisini de azaltt\u0131.<\/p>\n<h2>&#13;<br \/>\n\tAnormal sinir aktivitesinin bast\u0131r\u0131lmas\u0131<\/h2>\n<p>&#13;<br \/>\n\tAra\u015ft\u0131rmac\u0131lar ayr\u0131ca duyusal bilgiyi omurili\u011fe ta\u015f\u0131yan arka k\u00f6k ganglion n\u00f6ronlar\u0131n\u0131 da inceledi. Antikor tedavisinden sonra daha az n\u00f6ronda mekanik olarak ind\u00fcklenen h\u00fccre d\u0131\u015f\u0131 sinyalle d\u00fczenlenen kinaz (pERK) fosforilasyonu g\u00f6r\u00fcld\u00fc. N\u00f6ronal aktivasyonun bir belirteci olan pERK&#8217;teki bu azalma, antikorlar\u0131n anormal a\u011fr\u0131 sinyallerini bast\u0131rd\u0131\u011f\u0131na dair kan\u0131tlar\u0131 destekledi.<\/p>\n<p>&#13;<br \/>\n\tAra\u015ft\u0131rmac\u0131lar Nav1.7&#8217;yi bloke etmenin normal koruyucu a\u011fr\u0131y\u0131 zay\u0131flat\u0131p zay\u0131flatmayaca\u011f\u0131 konusunda da incelemelerde bulundu. Sinir hasar\u0131 olmayan hayvanlarda antikorlar\u0131n hi\u00e7biri mekanik uyar\u0131lara verilen tepkileri \u00f6nemli \u00f6l\u00e7\u00fcde de\u011fi\u015ftirmedi.<\/p>\n<p>&#13;<br \/>\n\tHayvanlar ayr\u0131ca hareket ve koordinasyonu \u00f6l\u00e7mek i\u00e7in kullan\u0131lan d\u00f6nen \u00e7ubuk testine tabi tutuldu. Pregabalin test edilen dozda performans\u0131 d\u00fc\u015f\u00fcr\u00fcrken, antikorlar motor fonksiyonu \u00f6nemli \u00f6l\u00e7\u00fcde etkilemedi.<\/p>\n<p>&#13;<br \/>\n\tDoktor Uta, Nav1.7&#8217;yi hedeflemenin normal koruyucu a\u011fr\u0131 hissini korurken anormal a\u011fr\u0131 sinyallerini susturmaya yard\u0131mc\u0131 olabilece\u011fini kaydetti.<\/p>\n<h2>&#13;<br \/>\n\tHayvan \u00e7al\u0131\u015fmalar\u0131ndan klinik testlere<\/h2>\n<p>&#13;<br \/>\n\tBulgular hen\u00fcz klinik \u00f6ncesi a\u015famada bulunuyor. Ara\u015ft\u0131rmac\u0131lar hasarl\u0131 sinire ne kadar antikor ula\u015ft\u0131\u011f\u0131n\u0131 tam olarak belirleyemedi ve tedavi sadece tek bir n\u00f6ropatik a\u011fr\u0131 modelinde de\u011ferlendirildi. Etkilerin di\u011fer modellerde ve insanlarda ge\u00e7erli olup olmad\u0131\u011f\u0131n\u0131 test etmek i\u00e7in daha fazla \u00e7al\u0131\u015fmaya ihtiya\u00e7 duyuluyor.<\/p>\n<p>&#13;<br \/>\n\tAntikorlardan S-151128&#8217;in halihaz\u0131rda klinik \u00e7al\u0131\u015fmalarda oldu\u011fu, ara\u015ft\u0131rmac\u0131lar\u0131n hayvanlarda g\u00f6r\u00fclen etkilerin n\u00f6ropatik a\u011fr\u0131s\u0131 olan insanlar i\u00e7in g\u00fcvenli ve etkili bir tedaviye d\u00f6n\u00fc\u015f\u00fcp d\u00f6n\u00fc\u015fmedi\u011fini test etmeye ba\u015flayabilece\u011fi belirtiliyor.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&#13; N\u00f6ropatik a\u011fr\u0131, hasarl\u0131 sinirlerin yeni bir doku hasar\u0131 olmasa bile a\u011fr\u0131 sinyalleri g\u00f6ndermeye devam etmesi nedeniyle bir yaralanmadan sonra devam edebiliyor. &#13; Yap\u0131lan yeni bir klinik \u00f6ncesi \u00e7al\u0131\u015fmada ara\u015ft\u0131rmac\u0131lar, a\u011fr\u0131yla ili\u015fkili bir sodyum kanal\u0131n\u0131 hedef alan antikorlar\u0131n, farelerde normal koruyucu a\u011fr\u0131 hissini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde sa\u011flam b\u0131rak\u0131rken anormal sinir sinyallerini g\u00fcnlerce bast\u0131rabildi\u011fini tespit etti. &#13; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":47893,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-47892","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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